The Correlation Between Kidney Function Tests and Complete Blood Count in Iraqi Patients with Chronic Hypertension

Main Article Content

Tamara Sami Naji
Shaimaa Khalid Moufak
Israa Ayoub Alwan

Abstract

Hypertension, also known as the silent killer, is a condition that typically remains asymptomatic until it causes significant harm to the cardiovascular system. Unmanaged hypertension can lead to renal failure, myocardial infarction, and even mortality. Kidney and blood pressure (BP) have a significant correlation with renal failure, particularly renal disease, leads to an increase in blood pressure. On the other hand, high blood pressure worsens the decrease in kidney function in those with kidney disease. This study aims to examine the correlation between kidney function tests (KFTs) and complete blood count (CBC) in Iraqi patients with chronic hypertension. The average disparity in kidney function tests (KFTs) between individuals with chronic hypertension and the control group. Urea, creatinine, and uric acid showed statistically significant increases (p<0.01). The findings indicated a noteworthy reduction (p<0.01) in HGB, HCT, MCH, and MCV concentrations among individuals with chronic hypertension. There is a strong and statistically significant association (p<0.01) between the average increase in urea and creatinine levels and the average reduction in MCH and MCV levels. Additionally, a significant correlation (p<0.01) exists between the uric acid level and deficiencies in HGB, HCT, MCH, and MCV. However, no statistically significant connection (p>0.01) was seen between HGB and HCT levels and urea and creatinine levels. Conclusions: Hypertension individuals with low levels of HGB, HCT, MCH, and MCV tend to have elevated levels of urea, creatinine, and uric acid. Thus, anemia may be advised for people suffering from hypertension and renal illness.

Article Details

Section
Articles

References

Balasubramaniyan, T., Samuel, H. U., Thirumavalavan, S., Vasudevan, C., & Kumar, R. P. S. (2020). A Study of Prevalence of Renal Diseases among Healthy Urban Population. J Clin Nephrol Ren Care, 6, 061.

Brzeźniakiewicz-Janus, K., Rupa-Matysek, J., Tukiendorf, A., Janus, T., Franków, M., Lancé, M. D., & Gil, L. (2020). Red blood cells mean corpuscular volume (MCV) and red blood distribution width (RDW) parameters as potential indicators of regenerative potential in older patients and predictors of acute mortality–preliminary report. Stem Cell Reviews and Reports, 16(4), 711-717. https://doi.org/10.1007/s12015-020-09977-6

Divya, R., & Ashok, V. (2016). A study of hematological parameters and anthropometric indicators in hypertensive and normotensive males. International Journal of Current Research and Review, 8(4), 6.

Draft Background & Scope. (2020). Treatments for Anemia in Chronic Kidney Disease". ©Institute for Clinical and Economic Review. 1-10.

Eun, Y., Han, K. D., Kim, D. H., Kim, I. Y., Park, E. J., Lee, S., ... & Kim, H. (2019). Association between anemia and hyperuricemia: results from the Korean National Health and Nutrition Examination Survey. Scientific Reports, 9(1), 19067.

Gebrie, A., Gnanasekaran, N., Menon, M., Sisay, M., & Zegeye, A. (2018). Evaluation of lipid profiles and hematological parameters in hypertensive patients: Laboratory-based cross-sectional study. SAGE open medicine, 6, 2050312118756663.

Ifeanyi, O. E., & Uzoma, O. G. (2016). Erythropoietin and kidney diseases: a review. J. Biol. Chem. Res, 33(1), 760-792.

Isra’a, H. A. (2010). Estimation of serum uric acid, urea and creatinine in essential hypertensive patients. Tikrit Medical Journal, 16(1), 152-158.

Kam-Tao Li, P., Garcia-Garcia, G., Lui, S. F., Andreoli, S., Fung, W. W. S., Hradsky, A., ... & Kalantar-Zadeh, K. (2020). Kidney health for everyone everywhere-from prevention to detection and equitable access to care. Nephrology and Dialysis, 22(1), 10-23.

Kiuchi, M. G., Chen, S., Carnagarin, R., & Schlaich, M. P. (2020). The role of afferent renal denervation in renovascular hypertension—another brick in the wall. Pflügers Archiv-European Journal of Physiology, 472, 323-324. https://doi.org/10.1007/s00424-020-02354-9

Lv, J. C., & Zhang, L. X. (2019). Prevalence and disease burden of chronic kidney disease. Renal fibrosis: mechanisms and therapies, 3-15.

Manjareeka, M., & Nanda, S. (2013). Elevated levels of serum uric acid, creatinine or urea in preeclamptic women. Int J Med Sci Public Health, 2(1), 43-47.

McAdams-DeMarco, M. A., Maynard, J. W., Coresh, J., & Baer, A. N. (2012). Anemia and the onset of gout in a population-based cohort of adults: Atherosclerosis Risk in Communities study. Arthritis research & therapy, 14, 1-8. https://doi.org/10.1186/ar4026

Muntner, P., Einhorn, P. T., Cushman, W. C., Whelton, P. K., Bello, N. A., Drawz, P. E., ... & 2017 National Heart, Lung, and Blood Institute Working Group. (2019). Blood pressure assessment in adults in clinical practice and clinic-based research: JACC scientific expert panel. Journal of the American College of Cardiology, 73(3), 317-335.

Palis, J. (2014). Primitive and definitive erythropoiesis in mammals. Frontiers in physiology, 5, 3.

Panjeta, M., Tahirovic, I., Karamehic, J., Sofic, E., Ridic, O., & Coric, J. (2015). The relation of erythropoietin towards hemoglobin and hematocrit in varying degrees of renal insufficiency. Materia socio-medica, 27(3), 144.

Sahu, S., Daniel, M., Abraham, R., Vedavalli, R., & Senthilvel, V. (2011). Study of uric acid and nitric oxide concentrations in preeclampsia and normal pregnancy. Int J Biol Med Res, 2(1), 390-393.

Tamanji, M. T., Ngwakum, D. A., & Mbouemboue, O. P. (2017). Variation of Serum Uric Acid with Renal Function, Fasting Blood Glucose and Blood Pressure in Northern Cameroonians with Essential Hypertension. Annals of Medical and Health Sciences Research.

Wasti, A. Z., Iqbal, S., Fatima, N., & Haider, S. (2013). Hematological disturbances associated with chronic kidney disease and kidney transplant patients. Int J Adv Res, 1, 48-54.

Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., ... & Desormais, I. (2018). 2018 Practice Guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. Blood pressure, 27(6), 314-340. https://doi.org/10.1080/08037051.2018.1527177

Zeng, C., Wei, J., Yang, T., Li, H., Xiao, W. F., Luo, W., ... & Lei, G. H. (2015). Higher blood hematocrit predicts hyperuricemia: a prospective study of 62897 person-years of follow-up. Scientific Reports, 5(1), 13765.